《公共科学图书馆·生物学》收录了在从分子到生态系统的所有生物科学领域中具有特殊意义、独创性和相关性的著作，包括化学、医学和数学等其他学科交叉领域的著作。我们也欢迎数据驱动的元研究文章，这些文章评估并旨在提高生命科学和其他领域的研究标准。我们的听众是国际科学界以及世界各地的教育工作者、决策者、患者倡导团体和感兴趣的公众成员。
PLOS Biology features works of exceptional significance, originality, and relevance in all areas of biological science, from molecules to ecosystems, including works at the interface of other disciplines, such as chemistry, medicine, and mathematics. We also welcome data-driven meta-research articles that evaluate and aim to improve the standards of research in the life sciences and beyond. Our audience is the international scientific community as well as educators, policy makers, patient advocacy groups, and interested members of the public around the world.