ISME杂志旨在促进微生物生态学的多样性和综合性领域，涵盖微生物生命的广度，包括细菌、古生菌、微生物真核生物和病毒。特别鼓励具有广泛生物学利益和影响的贡献。《日刊》范围内特别感兴趣的主题包括下列主题:
The ISME Journal seeks to promote diverse and integrated areas of microbial ecology spanning the breadth of microbial life, including bacteria, archaea, microbial eukaryotes, and viruses. Contributions of broad biological interest and impact are especially encouraged. Topics of particular interest within the journal's scope include those listed below: