杂志的主要焦点是数值线性代数，近似理论及其应用，微分和积分方程的数值解，计算复杂性，算法，计算机科学的数学方面，和最优化理论。Calcolo包含介绍新兴主题的说明性论文，以及博士论文摘要、会议新闻和报告，以及书评。
The main focus of the journal is on numerical linear algebra, approximation theory and its applications, numerical solutions of differential and integral equations, computational complexity, algorithmics, mathematical aspects of computer science, and optimization theory.Calcolo contains expository papers which introduce emerging topics as well as a abstracts of PhD theses, news and reports from conferences, and book reviews.